A randomized Phase I/II study to evaluate safety and reactogenicity of a heat-stable rotavirus vaccine in healthy adults followed by evaluation of the safety, reactogenicity, and immunogenicity in infants
نویسندگان
چکیده
منابع مشابه
Safety, reactogenicity and immunogenicity of a novel pneumococcal protein-based vaccine in adults: a phase I/II randomized clinical study.
BACKGROUND New vaccines containing highly conserved Streptococcus pneumoniae proteins such as pneumolysin toxoid (dPly) and histidine-triad protein D (PhtD) are being developed to provide broader protection against pneumococcal disease. This study evaluated the safety, reactogenicity and immunogenicity of different pneumococcal protein-containing formulations in adults. METHODS In a phase I d...
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15 صفحه اولThe human rotavirus vaccine RotarixTM in infants An integrated analysis of safety and reactogenicity
Rotavirus (RV) is a leading cause of severe acute diarrhea in infants and young children worldwide. RV gastroenteritis (RVGE) accounts for approximately 2.4 million hospitalizations and more than half a million deaths annually among children younger than 5 y. The burden of RV disease varies widely, but is significant in both developing and developed countries. The availability of safe and effec...
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ژورنال
عنوان ژورنال: Human Vaccines & Immunotherapeutics
سال: 2019
ISSN: 2164-5515,2164-554X
DOI: 10.1080/21645515.2019.1664239